<p>Novel lipophilic SN38 prodrug forming stable liposomes for colorectal carcinoma therapy</p>
نویسندگان
چکیده
منابع مشابه
Stable incorporation of a lipophilic daunorubicin prodrug into apolipoprotein E-exposing liposomes induces uptake of prodrug via low-density lipoprotein receptor in vivo.
Many tumors express elevated levels of low-density lipoprotein (LDL) receptors. Therefore, native LDL and synthetic LDL-like particles have been proposed as carriers for antineoplastic drugs. We demonstrated earlier that small apolipoprotein E (apoE)-exposing liposomes were specifically recognized by the LDL receptor. In this study, we incorporated a lipophilic derivative of daunorubicin (LAD) ...
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Highly lipophilic drugs can be used therapeutically only by the addition of possibly toxic solubilizing agents or by development of complex pharmaceutical formulations. One way of overcoming these disadvantages is the incorporation of such drugs into the bilayer matrix of phospholipid liposomes. To this end, we chose the approach of chemical transformation of water-soluble nucleosides of known ...
متن کاملhydrolysis-resistant lipophilic folate derivative enables stable delivery of targeted liposomes in vivo
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متن کاملA novel hydrolysis-resistant lipophilic folate derivative enables stable delivery of targeted liposomes in vivo
Instability of targeting ligand is a roadblock towards successful development of folate targeted liposomes. Folate ligands have been linked to polyethylene glycol (PEG) and cholesterol by an amide bond to form folate-CONH-PEG-CONH-Cholesterol (F-CONH-PEG-CONH-Chol), which is subject to hydrolysis. To increase the stability of folate ligands and promote the long circulation and targeting effects...
متن کاملOxaliplatin long-circulating liposomes improved therapeutic index of colorectal carcinoma
BACKGROUND Cytotoxic drugs are non-selective between normal and pathological tissue, and this poses a challenge regarding the strategy for treatment of tumors. To achieve sufficient antitumor activity for colorectal carcinoma, optimization of the therapeutic regimen is of great importance. We investigated the ability of oxaliplatin long-circulating liposomes (PEG-liposomal L-oHP) to provide an ...
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ژورنال
عنوان ژورنال: International Journal of Nanomedicine
سال: 2019
ISSN: 1178-2013
DOI: 10.2147/ijn.s204965